Cagrilintide is an amylin-analog, now being developed in combination with the GLP-1 agonist sem to achieve sustained weight loss in persons with overweight and obesity. These separate, but related mechanisms of action of an amylin-analog and a GLP-1 receptor agonist appear to have an additive effect on appetite reduction.  Cagrilintide alone, as well as cagrilintide in combination with sem have shown promising weight loss.

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