Depo-Estradiol (estradiol cypionate) injection is a hormone replacement therapy (HRT). It's used to relieve certain menopause symptoms, such as hot flashes and vaginal dryness. It can also raise estrogen levels in people who aren't making enough hormones. It's injected into the muscle about once every month. You can store Depo-Estradiol (estradiol cypionate) vials at room temperature, away from light. Some side effects of this medication include injection-site pain, headaches, and breast tenderness.

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